Paternal Lymphocyte Immunisation (PLI)
At Radha Hospital & Fertility Center, we know that repeated miscarriages or unexplained infertility can be heartbreaking for couples. Sometimes, these issues are linked to the immune system mistakenly rejecting the pregnancy.
Paternal Lymphocyte Immunisation (PLI) is an advanced immunotherapy treatment that helps a woman’s body accept and support a pregnancy by training the immune system to recognize the baby as “self” rather than “foreign.”
What is Paternal Lymphocyte Immunisation (PLI)?
PLI is a specialized fertility treatment where white blood cells (lymphocytes) are collected from the male partner and introduced into the female partner’s body.
The aim is to train the woman’s immune system to recognize the baby (which carries genetic material from the father) as “safe” rather than rejecting it. This helps prevent immune-related miscarriages and improves the chances of a successful pregnancy.
How Does PLI (LIT) Therapy Work?
The husband’s white blood cells are collected and purified.
These cells are injected into the skin of the female partner, usually in the arm.
This creates a type of immune tolerance in the woman’s body.
The immune system then learns to accept the developing baby, preventing miscarriage caused by immune rejection.
Who Needs PLI Treatment?
PLI may be recommended for women who:
Have recurrent pregnancy loss (two or more miscarriages)
Face unexplained infertility despite normal medical tests
Have multiple failed IVF cycles with no clear reason
Are diagnosed with immune-related fertility issues after special tests
Step-by-Step Procedure of PLI Therapy
Blood Collection – A small amount of blood is drawn from the male partner.
Processing – The lymphocytes (immune cells) are carefully separated in a sterile lab.
Immunisation – These cells are injected into the skin of the female partner, usually on the forearm, in tiny doses.
Immune Response – Over time, the woman’s body develops “blocking antibodies” that help protect and support the pregnancy.
Follow-up Sessions – Depending on medical advice, repeat sessions may be needed before or during pregnancy.
Advantages of PLI Therapy
Encourages successful embryo implantation
Reduces the chances of immune-related miscarriage
Improves the success rate of natural conception or IVF
Safe, simple, and minimally invasive procedure
Gives hope to couples with unexplained reproductive failures
Risks & Side Effects of PLI Therapy
PLI is generally safe but, like any treatment, it may cause minor side effects:
Redness, swelling, or itching at the injection site (temporary)
Mild fever or flu-like symptoms
Rarely, allergic reactions
All procedures at Radha Hospital & Fertility Center are performed under expert medical supervision to ensure maximum safety.
Frequently Asked Questions (FAQ)
1.Is PLI safe?
Yes, PLI is considered a safe and well-tolerated procedure when performed in specialized fertility centers.
2. How many sessions of PLI are needed?
This depends on individual cases. Some women may need 2–3 sessions before pregnancy, while others may need additional support during pregnancy.
3. Can PLI be combined with IVF?
Yes. PLI is often used along with IVF, ICSI, or IUI treatments to improve implantation and pregnancy success rates.
4. How soon can I try to conceive after PLI?
Usually, pregnancy can be attempted a few weeks after the therapy, depending on your doctor’s advice.
5. What is the success rate of PLI?
Success rates vary, but many women with recurrent miscarriages or unexplained infertility have achieved successful pregnancies after PLI therapy.
Why Choose Radha Hospital & Fertility Center for PLI?
Specialized expertise in reproductive immunology
World-class laboratory facilities for accurate and safe procedures
Personalized treatment plans tailored to each couple
Holistic fertility care including IVF, ICSI, IUI, and advanced immunotherapies
Compassionate support and counseling at every step
Our Commitment
At Radha Hospital & Fertility Center, we combine science, technology, and compassion to help couples overcome fertility struggles. With advanced treatments like Paternal Lymphocyte Immunisation (PLI), we give new hope to families dreaming of a healthy pregnancy.
Book Your Appointment Today
Take the first step towards parenthood. Schedule your consultation with our fertility experts to learn if PLI therapy is the right choice for you.